1. The class of immunoglobulins which can cross the placenta is

A. IgM
B. IgG
C. IgA
D. IgD

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2. Self reactive antibodies are not found in significant concentration in normal serum because

A. it is impossible to generate a self-reactive antibody
B. self reactive B cells are killed by CD8 T cells
C. B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide
D. self reactive B cells switch to IgA which is all secreted and not present in serum

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3. Simulation of which of the following will lead to appearance of first antibody to appear following stimulation by an antigen?

A. IgM
B. IgA
C. IgE
D. IgG

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4. Antigen binding sites of an immunoglobulin are located in

A. light chain alone
B. heavy chain alone
C. F_c region of the antibody
D. Fab regions of the antibody

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5. Which of the following mediates Type I hypersensitivity reaction?

A. IgE
B. IgG
C. IgM
D. IgD

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